Mandraki is the main village of the island and also the most populated settlement (660 residents). It is also the port where ferries from Kos
and other Dodecanese islands arrive. As such, it offers the widest choice of rooms to rent, restaurants and shops on the island. All tavernas and cafes are set along the sea, and the small souvenir shops, mini markets and bakeries are scattered in the small narrow streets between the houses.
Above Mandraki, on a 30 meters high rock rises up the Monastery of Panagia Spiliani
, which is built in the middle of a ruined fortress and has a cave church inside. The old castle of Nisyros
is even higher, on the top of a hill 3 km away from the village. There are two beaches in Mandraki. The smaller one is in the center, between the seafront tavernas. It has coarse volcanic sand with pebbles and rocks around the shore, and a few sunbeds. The other beach, called Hohlaki (Chochlaki) is a bit out of the village, below the Monastery of Panagia Spiliani. It is accessible via small path and has big smooth pebbles around the shore, and volcanic lava formations in one end. Hohlaki has no facilities at all and it can be seen from the monastery yard.